TAMIFLU Capsules 75[for treatment] 抗流感病毒剂 磷酸奥司他韦胶囊 [0114987136100251]

TAMIFLU Capsules 75[for treatment] 抗流感病毒剂 磷酸奥司他韦胶囊 [0114987136100251]

Price: US$344.30(tax included)

List Price: US$413.20

Weight: 100g

Sold out
Quantity:

Item description

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
TAMIFLU Capsules 75[for treatment]
 Active ingredient:
Oseltamivir phosphate
 Dosage form:
pale yellow/light gray capsule (major axis: approx. 17.8mm)
 Print on wrapping:
タミフル75mg

Effects of this medicine

This medicine blocks influenza virus from leaving the infected cell in order to suppress viral reproduction.
It is usually used to treat influenza type A and type B infection. 

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you are a patient with renal function disorder.
    If 48 or more hours have been passed since you had influenza symptoms.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults and children weighing 37.5kg or more, take 1 capsule (75mg of oseltamivir) at a time, twice a day, for 5 consecutive days. Strictly follow the instructions.
  • If you miss a dose, take the missed dose as soon as possible. However, you should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so. Note that in some cases, it is difficult to differentiate side effects of this medicine and influenza symptoms such as fever, runny nose, sore throat, muscle pain, headache, cough, loss of appetite, general malaise, chills and diarrhea.

Precautions while taking this medicine

  • Abnormal behavior has been reported in patients infected with influenza, regardless of the use or non-use, or the type of influenza antiviral medicine prescribed. Please pay attention to the following points to prevent accidents such as falls due to abnormal behavior.
    - Abnormal behavior(run suddenly, wandering etc.)
    - Caregivers should take preventive measures for accidents including falls for at least 2 days after patients develop fever if they are treated at home.
    Severe abnormal behavior is known to have been reported to occur with greater frequency in male school-age children/adolescents, and to appear within 2 days after developing fever.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, abdominal pain and nausea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • cold sweat, lightheadedness, dizziness, pale face, itchy throat, palpitation, breathing difficulty, cold limbs, general itch, hives, loss of consciousness [shock, anaphylaxis]
  • fever, cough, phlegm, shortness of breath, breathing difficulty [pneumonia]
  • easy fatigability, general malaise, loss of strength, acute decreased consciousness, yellowing of the white of eyes, vomiting of blood, nausea, yellowing of the skin, itch, acute weight gain, dark urine, enlarged feeling of abdomen, loss of appetite, lead to blood in the stool(scarlet to dark red stool) [fulminant hepatitis, hepatic function disorder, jaundice]
  • fever, inflamed/sore eye, lip/intraoral sore, boil with the circular bulge by edema in the marginal region of circular spot, widespread redness in the skin and multiple breakable blister, mucous sore [mucocutaneous ocular syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (TEN)]
  • decreased urinary volume, edema, general malaise [acute kidney injury]
  • sudden high fever, chills, sore throat  [leukopenia]
  • nose/gum bleeding, bruise, continuous bleeding [thrombocytopenia]
  • decreased consciousness, impaired mind/judgment, seeing or hearing something that is not really there, groundless belief, strong belief in something untrue, convulsion, unusual bizarre behavior, abnormal behavior, run suddenly, wandering [psycho-neurologic symptoms (consciousness disorder, delirium, hallucination, delusion, convulsion, etc.) , abnormal behavior]
  • fever, lightheadedness, shortness of breath, sudden abdominal pain, severe abdominal pain, bloody diarrhea [hemorrhagic colitis, ischemic colitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store at room temperature (1 to 30℃), away from direct sunlight and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacist or healthcare facility how to discard them.

简介:

商品名:Oseltamivir Phosphate
英文名:Tamiflu Capsules
中文名:磷酸奥司他韦胶囊
生产商:中外制药


药品简介
Tamiflu(oseltamivir phosphate)是一种抗病毒药。用于治疗A型和B型流感病毒感染的抗病毒药物。在开始使用该药物治疗之前,必须先评估肝和肾功能。这种药物不应该用于预防1岁以下儿童的流感。
タミフルカプセル75
药物类别名称
抗流感病毒剂
批准日期:2001年2月
商標名
Tamiflu Capsules
一般的名称
オセルタミビルリン酸塩(Oseltamivir Phosphate)(JAN)

 

药效药理
作用机理
磷酸奥司他韦的活性形式选择性抑制人甲型和乙型流感病毒的神经氨酸酶(IC50:0.1-3 nM),并抑制新形成的病毒从感染细胞中释放。抑制增长。
体外抗病毒作用
磷酸奥司他韦是一种前药,在被代谢转化为活性形式后,具有抗病毒作用。
磷酸奥司他韦的活性形式以低浓度抑制了体外甲型和乙型流感病毒的复制(实验室菌株IC50:0.6-155 nM,临床分离株IC50:<0.35μM)。


体内抗病毒作用
在小鼠和雪貂的A型和B型流感病毒感染模型中,口服奥司他韦磷酸酯(0.1-100 mg/kg/天)在存活率方面呈剂量依赖性增加,并减少与感染有关的症状。观察到诸如病毒滴度降低的治疗效果。在鸡感染模型中,观察到从病毒感染前24小时开始口服给药(1100mg/kg,每天两次)可以抑制病毒感染,例如提高存活率。
抵抗性
在国外和国内临床研究中,对该药物产生抗药性的病毒在成人和青少年(13岁及以上)中为0.67%(15 /2,253例),在幼儿(1至12岁)中为4.24%(72/1,698例)。新生儿和婴儿(1岁以下)占18.31%(13/71例)。所有抗性病毒均衍生自A型病毒,在B型病毒中未观察到出现。抗药性获得性病毒在小鼠和雪貂中的感染性降低,据认为该病毒在感染部位的生长和传播较低。在抗性病毒中发现了神经氨酸酶中​​的氨基酸突变。

 


适应症
甲型或乙型流感病毒感染及其预防

 


用法与用量
通常,对于体重37.5千克或以上的成人和儿童,奥司他韦以75毫克的剂量口服,每天两次,共5天。

成人
通常,每天一次口服75毫克奥司他韦,持续7至10天。
37.5公斤或以上的儿童
通常,每天一次口服75毫克奥司他韦,持续10天。



制造商
中外制药有限公司

Facebook Comments

Reviews

0 reviews