REZALTAS COMBINATION TABLETS HD x100c 高血压降压药 奥美沙坦配合錠 [0114987081102409]

REZALTAS COMBINATION TABLETS HD x100c 高血压降压药 奥美沙坦配合錠 [0114987081102409]

Price: US$203.20(tax included)

List Price: US$243.80

Weight: 90g

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Item description

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
REZALTAS COMBINATION TABLETS HD
 Active ingredient:
Olmesartan medoxomil
 
Azelnidipine
 Dosage form:
one surface white, one surface white to yellowish white tablet (major axis: 14.2 mm, minor axis: 6.7 mm, thickness: approx. 5.3 mm)
 Print on wrapping:
(upper side) レザルタス配合錠HD, レザルタスHD, DSC373, オルメサルタンメドキソミル20mg/アゼルニジピン16mg
(under side) RezaltasHD, オルメサルタンメドキソミル20mg/アゼルニジピン16mg, レザルタスHD, 高血圧症のお薬です

Effects of this medicine

This medicine is a combination preparation of an angiotensin receptor blocker and a calcium antagonist. It lowers blood pressure by suppressing the vasoconstriction action of angiotensin II in vascular smooth muscles with angiotensin receptor blocker, and by dilating blood vessels with calcium antagonist. 
It is usually used in the treatment of hypertension.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you have: renal artery stenosis, hyperkalemia, renal disorder, hepatic disorder, cerebrovascular disorder.
  • If you are on hemodialysis, or on a strict low-salt diet.
  • If you are pregnant, possibly pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, take 1 tablet at a time, once a day after breakfast. Strictly follow the instructions.
    The medicine contains 20 mg of olmesartan medoxomil and 16 mg of azelnidipine in 1 tablet.
  • If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • The medicine may cause dizziness or lightheadedness by decreasing blood pressure. Pay close attention when you work at heights, drive a car or operate dangerous machinery.
  • Do not drink grapefruit juice while you take the medicine because it may cause an excessive hypotensive response by increasing blood level of the medicine.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include dizziness and headache. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • breathing difficulty, swelling in the eyelids/lips/tongue, hives [angioedema]
  • decreased urine output, edema, headache  [renal failure]
  • numbness in the limbs and lips, muscular weakness, paralysis in the limbs  [hyperkalemia]
  • cold feeling, vomiting, faint, loss of consciousness  [shock, faint, loss of consciousness]
  • general malaise, loss of appetite, yellowing in the skin/white of eyes  [hepatic dysfunction, jaundice]
  • nasal bleeding, gums bleeding, subcutaneous bleeding  [thrombocytopenia]
  • cold sweat, hungry feeling, lassitude  [hypoglycemia]
  • dizziness, lightheadedness  [atrioventricular block, sinus arrest, bradycardia]
  • muscle pain, lassitude, red-brown urine  [rhabdomyolysis]
  • itch, general redness, blood pressure falling, decreased consciousness, palpitation [anaphylaxis]
  • nausea, severe stomachache, water-like stool [severe diarrhea]
  • fever, dry cough, respiratory distress, shortness of breath [interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out the reach of children. Store away from light, heat and moisture. 
  • Discard the remainder. Do not store them.

简介:

英文药名:REZALTAS COMBINATION TABLETS LD/HD(Olmesartan Medoxomi/Azelnidipine)
中文药名:奥美沙坦/阿折地平配合錠LD/HD
生产厂家:第一三共有限公司
药物分类名称
高亲和力ARB /持续性Ca拮抗剂组合
批准日期:2010年4月
商標名
REZALTAS COMBINATION TABLETS

 

药效药理
奥美沙坦酯是一种前药,口服给药,主要由在小肠上皮酯酶水解后,被转换为奥美沙坦的活性代谢物。存在于血浆奥美沙坦小,选择性地作用于血管紧张素II(AII)类型1(AT1)受体和竞争性抑制AII的结合,强烈药理作用被升压基于AII通过抑制节目持续的降压作用。奥美沙坦酯是在高肾素型高血压模型肾素 - 血管紧张素系统(RAS)被激活表示显著降压作用,相反,在低肾素型高血压模型降压作用涉及很少RAS弱这是已知的。阿折地平是基于L-型Ca通道拮抗作用,表达通过扩大容器降血压作用。阿折地平是肝脏首过效应较不敏感,抗高血压作用是通过缓慢持续。阿折地平,不同于奥美沙坦酯,它显示了在低肾素型高血压模型要比高肾素型高血压模型较强的降压作用。
由于这种药物是奥美沙坦酯联合使用,具有高肾素特性的显着降血压作用和对高肾素抗性和高血压有强烈抗高血压作用的阿魏酸,对高血压病因而言是稳定的抗高血压作用这将表明。

降圧作用
通过在自发性高血压大鼠中口服奥美沙坦酯和氮n啶,与单次给药相比,观察到降压作用增加。 在单独施用奥美沙坦酯或阿兹尼地平的高血压模型(肾高血压大鼠/ DOCA盐高血压大鼠)中,奥美沙坦酯和azelnidipine的组合给药显示出显着的降压作用。

 


适应症
高血圧症

 


用法与用量
每天吃一片(10mg/8mg或20mg/16mg)早餐后口服给成年人使用。 该药不用作高血压治疗的一线治疗。

 


制造厂商
第一三共有限公司

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