Rozerem Tablets 8mg100c 安眠药 雷美尔通片 [0114987123143933]

Rozerem Tablets 8mg100c 安眠药 雷美尔通片 [0114987123143933]

Price: US$138.60(tax included)

List Price: US$166.30

Weight: 40g


Item description

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Rozerem Tablets 8mg
 Active ingredient:
 Dosage form:
pale orangish yellow tablets, φ7.1 mm, thickness 3.6 mm
 Print on wrapping:
(Face) ロゼレム 8mg 157 (Back) ロゼレム8mg

Effects of this medicine

This medicine brings the brain and body into “a state of readily going to sleep” by regularizing the sleep-awake rhythm via its acting upon the receptor for “melatonin,” a hormone deeply involved in the sleep mechanism.
Usually, used for treatment of insomnia.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
    If you have liver disorder, sleep apnea syndrome, or brain disorder.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • General dosage regimen: for adults, take 1 tablet (8 mg of the active ingredient) at a time, once a day, at bedtime. Do not increase the prescribed dose at your own discretion just because you still remain awake. Strictly follow the instructions of your doctor/pharmacist.
  • Do not take the medicine while eating a meal or immediately after a meal.
  • Do not take the medicine if you are intending to get up partway and do some work.
  • If you missed a dose at bedtime, awoke halfway and remained wakeful, you may take a dose if there is a considerable time until your getting up the following morning. If the remaining time is insufficient, you may be bothered by oversleeping, or experience some carryover effect of the medicine such as sleepiness or light-headedness on arising. DO NOT take double doses to make up for the missed dose.
  • If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
  • Do not stop taking the medicine without the instructions of your doctor.

Precautions while taking this medicine

  • As some carryover effect of the medicine may persists the following morning and thereafter, avoid operating dangerous machinery such as driving a car.
  • Refrain from alcohol drinking while taking the medicine because the effect of the medicine may be potentiated by alcohol.

Possible adverse reactions to this medicine

Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: dizziness, headache, sleepiness, rash, constipation, nausea, malaise, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • rash, swelling of the face/tongue/throat, breathlessness [anaphylactic symptoms (hives, angioedema, etc.)]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and humidity.
  • Discard the remainder. Do not store them. If you dispose of unused medicines, seek advice of your pharmacist about proper disposal of drugs.



商品名:Rozerem Tablets
英文名: Ramelteon
中文名: 雷美尔通片


Rozerem Tablets 8mg.



1. 作用机制
Ramelteon 是一种褪黑激素受体激动剂, 对褪黑激素MT1和MT2受体有较高的亲和力, 对人的褪黑激素MT1和mt2受体的亲和力(Ki值)分别为14.0pmol/L和112pmol/L。在福斯科林诱导的cAMP生成反应指数中, 激动剂活性的IC 50值分别为21.2pmol/L 和53.4pmol。Ramelteon是GABA, 包括GABAA受体, 血清素, 多巴胺, 神经递质受体, 如去甲肾上腺素和乙酰胆碱, 不表现出可检测的亲和力, 浓度为10[mu]mol只能。
2. 对睡眠的影响
口服0.03mg/kg对仙人掌夜间睡眠的影响显著降低了较浅NREM睡眠和慢波睡眠的潜伏期, 显著增加了总睡眠量。
在对猫睡眠觉醒的作用下, 通过口服拉梅特翁0.001mg kg缩短苏醒时间, 显著增加慢波睡眠时间。






通常情况下, 成人在睡觉时口服一次8毫克。



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